Iqembu laphesheya kososayensi baseMelika nabaseShayina baqhuba isifundo lapho afunda khona ubuhlakani bokusakazeka kwe-coronavirus eBritish. Kwavela ukuthi ukuthambekela kokuguqulwa kokuqala kwenza ukuthi kube nokukwazi ukuxhumana nomzimba womuntu amahlandla ayi-10.
Ezinhlelweni zocwaningo, ososayensi abamele i-University of Colorado (USA), kanye nozakwabo baseShayina balungiselela inani elikhulu lamakhophi amaprotheni aseBrithani, azama ukuwaxhumanisa ne-Ase Receptors2, ngokuhambisana nokuhlangana kwabo. Futhi, imiphumela yokuhlolwa yaqhathaniswa nemiphumela yalokho izilinganiso ezikhiqizwe enye inqwaba yeCoronavirus, engenawo isimilo se-N501Y sokuguqulwa kweBritish. Njengoba kwenzeka, isici soshintsho oluncane lwamaphuzu e-RBD Protein sakhiwo, esibhekele i-SARS-Cov-2 Compound ngeseli, ngcono kakhulu amandla we-pathogen ukwakha ukuxhumana ne-Ase Repeptors2. Kuyaphawulwa ukuthi ngokwesilinganiso, le nkomba idlula kasishumi, okuthi, ngokusho kochwepheshe, imvamisa ifana nomehluko phakathi kweCoronavirus yohlobo olusha kanye nokubalwa kwayo, okuyi-SARS-CoV, okuyi-Atypical Pneumonia.
Ukuphawula ngemiphumela yokubalwa, odokotela bathi ushintsho olwambuliwe ekusebenzeni kwamaprotheni e-RBD kungenxa yekhono lokushintsha ekwakhekeni kwamanani e-hydrogen ahambisana nawo ngesikhathi sokuxhumana kwawo ngesikhathi sokuxhumana kwawo ngesikhathi sokuxhumana kwawo. Ngaphezu kwalokho, izazi ze-microbiologists zithole ezinye izinguquko eziningi ezithinta i-complec yama-molecule, kepha indima yalezi metimorphosis kufanele ihlolwe. Kepha vele, ososayensi baphawule ukuthi ushintsho olushiwo luyakwazi ukunciphisa kakhulu ukusebenza kwesenzo esinikezwe ama-antibodies e-monoclonal kuma-microin striain. Kodwa-ke, ngokusho kochwepheshe, amandla okuphikisana naleli gciwane ngokumelene ne-Covige-19 imigomo yokulwa negciwane lifanelekile, yize kungenjalo ngezinguqulo ezedlule ze-SARS-CoV-2.
"I-British Coronavirus Grains inamaphuzu wokuguqulwa kwamaphuzu uN501Y, eshintsha ukwakheka kweprotheni ye-RBD, ebhekele ukunamathisela leli gciwane ku-ASA2 receptors endaweni ecishe ibe yishumi. Xhumana nalawa amaprotheni amaseli abantu, "ama-resum aholayo ohola umsebenzi wesayensi, uSolwazi Philip Marrah. Izifundo zithunyelwa kwimithombo ye-biologx ye-elekthronikhi ye-elekthronikhi.