Ososayensi bakwamanye amazwe banikeze incazelo yokuthi abanye abakhileyo emhlabeni basebenzisa uphuzo oludakayo kukhona ubomvu wesikhumba ebusweni nakwezinye izingxenye zomzimba. Ngokusho kochwepheshe, ukusabela komzimba okunjalo kubangelwa yileveli encishisiwe yokuba khona kwenye yama-enzyme.
Ososayensi bakhumbula ukuthi ukuhlukaniswa kotshwala esibindini kwenzeka ezigabeni ezimbili. Ikakhulu, isigaba sokuqala kungenxa yokuguqulwa kotshwala utshwala deHydrogenase e-Acetaldehyde, ukunqwabelana kwawo, ngesizathu, kuyisizathu sokubonakala kwe-hangover kubantu. Esigabeni esilandelayo, umphumela wesibili kusuka kuma-enzyme, i-Aldehydehydrogenase ibangela i-acetaldehyde ukuphendukela ku-acetic acid. Ochwepheshe baphawule ukuthi ukusilela kwalesi sici kubonisa ukuthi abantu abahlala eMpumalanga Asia - amaJapan, amaKorea namaShayina. Kulokhu, ingxenye yabantu iveze ifa lamakhophi amabili ohlobo oluguqukayo olufaka le enzyme. Ngenxa yalokho, isibindi sabanye abantu asikwazi ukuhlanganiswa kwe-Aldehydehydehydehydrogenase ngesakhiwo esifanele. Abanye, nabo, badla ifa kuphela ngohlobo oluguqukayo, oluholela ekwakhiweni kwenguqulo enesici ye-enzyme kwezinye izimo. Ngenxa yalokhu, esimweni sokuba khona kokwehla okuphelele noma okuyingxenye kwe-alldehydehydhydrogenase emzimbeni, kugcinwa izinga eliphakeme le-acetaldehyde, okuholela emiphumeleni ye- "Hangoveave, ukujuluka, ikhanda, ukushaya kwenhliziyo okusheshayo , isiyezi futhi, kufaka phakathi ukubomvu kwesikhumba ebusweni noma kwezinye izingxenye zomzimba.
Odokotela baphawule ukuthi ukuba khona kokushoda kwe-Aldehydehydhydrogenase kuvame kakhulu kudlala indima enhle emzimbeni, njengabantu abanesici esinjalo, ngenxa yokuba khona kwemiphumela emibi engenhla, kuvame kakhulu ukuhlushwa umlutha weziphuzo zotshwala. Ikakhulu, ngokuya ngezibalo, abamele abamele abantu baseMpumalanga Asia akuvamile ukuba zibe nezifo ezihambisana notshwala. Ngakolunye uhlangothi, uma umuntu enamazinga ancishisiwe engxenye ebekiwe esenokujwayelekile ukusebenzisa utshwala obuningi, umkhuba onjalo ungaholela engcupheni eyandayo yokuthola umdlavuza we-acophageal.