Izazinzulu zaseJamani zifunda ubume bentsholongwane ye-SARS-2 ye-TOV-2 esebenzisa imodeli ye-3D. Ukufakwa kwe-molecular ye-coronavirus kuya kunceda ekufumaneni ukusebenza ngokulwa nezithako zePathogen.
Ugqirha webhayoloji yesakhiwo waseWürz Andrea thana ukusuka ekuqaleni kwe-phandemic uzama ukuthobela amacandelo eproteyini e-SARS-2. Oku kuyimfuneko ukwenzela ukuba abaphuhlisi bokugonya kunye neziyobisi kwihlabathi liphela ukufumana iindlela zokhuseleko iBerliner Zeitung. Kudliwanondlebe noshicilelo, ingcali yathi yombulelo ngokuqonda ngokuchanekileyo isakhiwo semolekyuli ye-coronavirus kunye nobukho beemodeli zabo, unokufumanisa ukuba isebenza njani intsholongwane. Umzekelo, ukuba ubamba iseli yabantu kwaye iyenza ivelise ivelise iintsholongwane, inyathelo ngalinye lenziwe ngemolekyuli yeprotein. Ke ngoko, ukunqunyulwa kwale protein kuthetha ukuyeka usulelo.
Ibukeka njani i-SARS-Cov-2?
I-Coronavirus ayijikelezi. Ijongeka ngathi yi-bubble yesepha kwintshukumo engapheliyo. Umaleko wangaphandle utyebile uthambile kwaye une-acids enamafutha anamachiza afana nesepha. Ngenxa yoko, isepha inokuyichitha ngokupheleleyo igobolondo yentsholongwane - ngokuxhomekeka ekubeni isandla sihlambe ngokwaneleyo. Umaleko wangaphandle ugutyungelwe nge-spikes ebizwa ngokuba yintsholongwane evumela intsholongwane ukuba ingene kumzekelo kwiiseli zemiphunga. Kodwa isibakala sokuba abaninzi babiza intsholongwane eneneni le yi "uhlobo lweSoft" lezothutho ". Ngaphakathi kuthwala izinto zeprofayili kwiimolekyuli ezingama-28. Uninzi lwalo lwakhiwe kuqala kwiseli ye-ndwendwe ukuze uyiguqule ibe yinto yokuveliswa kweentsholongwane.Uninzi lukholelwa ukuba iintsholongwane azinakubonakala. Basenokungaboni ukuba imifanekiso yemibala eboniswe kwimithombo yeendaba yimifanekiso yentsholongwane. Intsholongwane kunye nengozi yayo ayibonakali. "Abantu ababoni ukuba abaninzi abafileyo abayiboni ngokupheleleyo amasebe okubaleka ngenxa yokuba kukho ukuvalwa. Ikwayinye yezizathu zokuba nathiwe kwaye ziprinta
Ukwenza ingozi kuyaqondakala ngakumbi, "i-biologi yaphawula.
Indlela yokuNgqinisisa Imolekyuli
Iingcali zilinganisa intsholongwane yonke, kodwa i-molekseli yayo kuphela. Injongo yeengcali zebhayoloji zesakhiwo kukukhangela enye yeeproteni ezingama-28 ezahlukeneyo zamacandelo e-SARS-2. Omnye umsebenzi kukukrokrela iprotein yeqanda. Ikristali inobungakanani beshumi le-millimeter kwaye iquka amawaka eemolekyuli ezifanayo. Ke le ekrizeki ilinganiswa isebenzisa i-X-rays kwi-Synchrotron i-Synchrotron i-Aclarator yamasuntswana njengeBersin II eBerlin. Le datha iphinde isivumela ukuba senze imodeli emithathu yemowudi ye-imeyile yekristale.
Njengenxalenye yesifundo, iimodeli zenziwa kwisiseko semilinganiselo efunyenweyo ihlolwe kwaye iphuculwe. Amalungu eqela le-Andrea Tern alandelwa yi-AOTO eboniswa kwi-3D ye-3D. Ukuzala kweentsholongwane kunokuthatha ukusuka kwiinyanga ezi-1 ukuya kwezingama-36 ngokucoca kude kube kusebenza. Iprotein ye-EGG ineeprotery ukusuka kwiinyanga ezi-1 ukuya kwezi-24. Ukulinganisa kwi-synchrotrotron kuthatha malunga nemizuzu emithathu. Ukuqokelelwa kwedatha kunye nendibano yezakhiwo ngoncedo lwamanqaku akhethekileyo ahlala kwiveki ukuya kwiinyanga ezine yingcali echazwe.
Ukuza kuthi ga ngoku, izazinzulu zilinganisa i-17 yeentombi ezingama-28 zeentsholongwane. Ngelixa izakhiwo azininzi kakhulu - inkcazo ithatha iiveki okanye iinyanga ezingaphezulu - kodwa ezi zinto zinokumodareyithwa ngokulula kwikhompyuter. Ekubeni nje amawaka amawaka emolekyu atshintshiwe. Emva kobhubhane, inani lezifundo sele linciphile kakhulu kwaye alisaxhaswa. Ugqirha webhayoloji ngokwendalo ukholelwa: Ukuba izifundo ze-SARS-2 zaziqhutywa rhoqo izazinzulu ziya kuba nolwazi ngakumbi malunga ne-coronavirus. Inokuba yingenelo enkulu kwaye ivumele ukuba ilungiselele ngcono ibhujeki elandelayo.