I-abute myloid leukemia (OML) i-turub ye-prood yegazi-ithathwa njengeyona ntlobo kwabantu abanomhlaza wegazi, ukubulala abaguli abathathu abaneminyaka emihlanu. Nangona malunga ne-70-80% yezigulana ezine-oml phantsi kweminyaka engama-60 ubudala ifikelela ngokupheleleyo, uninzi lwendlela yokuphinda luyenzeka kakhulu "
Enye yeengcinga ezithandwayo namhlanje yile, kuba ayizizo zonke iiseli ze-turum ziyafana kwinqanaba lemvelo (oko kukuthi, linokumelana nonyango), obangela ukukhula okuphindiweyo. Elinye ingcinga ithi: Ukuphinda-phinda ngexesha le-leukemia kwenzeka ngenxa yokunganyangeki ngamachiza ukuya kwiselfipurating yeeseli ezinokutshintsha ithumbu. Ke ngoko, ngokokujonga, kusesele kwiiseli ze-IML nge-IMLONGOPONOTPE (CD34 +) I-CD38-) i-chemotherapy ikwazi ukusinda ngokutsha kweeseli zomhlaza okanye ezonakalisayo zona. Nangona kunjalo, ezinye izifundo zakutshanje zibonise ukuba ezinye izinto zinoxanduva lokuphinda ziphinde zihlaziywe kwaye zigonyiwe kwi-chemotherapy.
Ukufumanisa ukuba kutheni i-IML ibuyela emva konyango, izazinzulu zizamile kwiYunivesithi yaseVirginia, i-Wile yeKholeji ye-Fox Chase Chase kunye neYunivesithi yasePennsylvania kunye neYunivesithi yasePennsylvania kwiDyunivesithi yaseMzantsi Ostreliya. Izigqibo zabo zinokufumaneka kupapasho lwephephancwadi lomhlaza imagazini.
"I-culute myloid leukemia ingaya kwinyathelo lokuxolelwa kusetyenziswa i-chemotherapy, kodwa ihlala ibuya ibuya. Xa oku kusenzeka, isifo asinyangeki, "utshilo uGqirha Ari M. Melnik, uNjingalwazi we-Hematology kunye nekoncotology. -Umbuzo mdala kule ndawo uvakale ngolu hlobo: "Kutheni le nto ingakwazi ukususa zonke iiseli zomhlaza?" Umbuzo ofanayo unokusetwa kwimeko yezinye iintlobo zomhlaza onoburharha, ukongeza kwi-IML.
Olu phando lwenziwa zombini kwii-organoids nakwiigco zelebhu, eziphakanyisiweyo iiseli zomhlaza. Iziphumo zaye zaqinisekiswa kwiisampulu ezithathwe kwizigulana ezine-culuted leukemia ngexesha lonyango kunye nokuphindaphinda. Njengoko izazinzulu zifumanisa ukuba iiseli ze-leukemia zahlanjwa, inxenye yazo idluliselwa ziimpawu "zokusebenza okuqinisekileyo kweHibernation": zibonakala zifuna imisebenzi yazo kwaye zatsala iiseli zomzimba zazo zitsalele umnxeba.
I-Geotouch Adheratherapy, ukongeza kwi-Apoptosis, ixhaphaza amandla - ukuphinda uxinzelelo lweseli kubonakaliswa ngumsebenzi we-abertant. Inguqu 'kwimodi yokulala "yavumela iiseli zesisu ukuze siphile oku: Ngenxa yendlela yokumelana nokuchasana nokwaluphala. Ngokutsho kwezazinzulu, isiphumo sokwaluphala sethutyana kwaye sinike ithuba elihle lokuqulunqa iikoloni, kwaye emva kokubuyiselwa kweseli ye-OML ebangelwa kukuphinda kwenziwe izinto ezahlukeneyo ze-stem.
"Oku kuhlala kujongwa ekuphuhliseni imibungu amisa kakhulu ukukhula kwawo okwethutyana ngenxa yokunqongophala kwesondlo. Ithamsanqa likwabizwa ngokuba yi-Bloranic Diepause, - yongeze i-melnik. Ayisiyonkqubo ekhethekileyo, kodwa yinto eqhelekileyo yebhayiloji, ebonakalisa imeko yamathumba. "
Izifundo zesifundo zifumanise ukuba imeko yokuguga kunye neeseli zethumba kwiseli ye-tumor ibangela iprotein ye-ATR TIREIN, iprotein ye-Telangine yeTelaxinane, i-ATR ye-ATR3 (Frp1)). Oko kukuthi, kusengqiqweni ukuvimba i-Atr ukuze iiseli zomhlaza aziwele kwi-hibernation. Emva kweemvavanyo elabhoratri, izazinzulu ziqinisekisile ukuba ukungeniswa kwe-inhibin ye-protein - i-Ve821 - iiyure ezingama-24 ngaphambi kokupheliswa kwe-chemotherapy inceda ukuba ubulale zonke iiseli zethumba.
Ngoku izazinzulu zisebenza neenkampani-abavelisi abavelisi baseTarr. Ewe kunjalo, kuya kufuneka uphendule imibuzo malunga nokuba ixeshana kwaye njani unyango oluya kumiselwa njani. Nangona kunjalo, ezinye izifundo ezifanayo sele zibonise ukuba imeko yokwaluphala kunye "nokusebenza" ibaluleke kungekuphela kwimeko ye-leukemia ye-Akukemia, kodwa nakwimihlaza ephindaphindiweyo ephindaphindiweyo, i-Prostate okanye isisu.
Umthombo: Inzululwazi yezeSwaziya