Kwiimeko ezininzi, iiseli zomhlaza Iiseli zahlukile kwi-chromosome enempilo-le nto ibizwa ngokuba yi-Aneuploidia. Ifumaneka kwi-90% yamathumba amangange-75% yezifo zegazi zomhlaza. Ngokwesiqhelo, ebantwini, bakuqokelelwa ngamabini angama-23, kodwa xa iiseli zomzimba ziphelile, zinomhlaza, inani lezakhiwo ezigciniwe.
Isifundo se-kaRotyty Anomalies (iseti yeempawu ze-chromosomal) sezisele zenziwa ngamashumi amabini eminyaka idlulileyo, kodwa ihamba nobunzima obukhulu. Iingcali kwiYunivesithi yaseTel Aviv (Tel Aviv University) zimisele ngokwakho ukufumanisa ukuba ingakanani inqanaba le-aneuploidy kwiimeko ezahlukeneyo ze-Oncology iyahluka.
Kule nto, bakhulisa malunga namawaka ezityalo ezahlukeneyo zeeseli zomhlaza ezithathwe kwizicubu zehlabathi. Ngoncedo lweendlela eziphambili ze-bioineforformformformatics zenkcubeko zahlulwa ngokwenqanaba le-Aneuploidy. Oku akuncedisi bhetele ukuba baqonde ngcono ukungavisisani kwe-chromosomal ye-chromosomal kwimisebenzi ebiweyo, kodwa yenza ukuba ukwenze ukuba kufundwe ngumahluko phakathi kweeseli ezivela kwi-KAROTYTE. Kuphela kwinkulungwane XX, zebhayoloji banethuba ukwenza umsebenzi onjalo usebenzisa iikhompyutha yamandla software - inani imiqondiso ezimakhulu mathathu anamanci mathathu zihlalutywe.
Iphelile ukuba iiseli zomhlaza zinento enye ebalulekileyo eyahlula kuba sempilweni. Ewe babelane ngokungalawulekiyo kwaye benze okungakumbi ngakumbi, kodwa kunovelwano ngakumbi ngokwaphula elinye lamanqanaba ale nkqubo. Okanye endaweni yoko, iingxaki ezivela ngexesha elibizwa ngokuba yindawo yokulawula umjikelo weseli phakathi kweMetafani kunye ne-mitosis (SAC). Iiseli eziqhelekileyo ziyakwazi ukuphelisa iimpazamo ezibonakala ngexesha le-SAC ukuya kwinqanaba elithile. Umhlaza ngomgangatho ophezulu we-Aneuploid-Rale, nokuba inani leengxaki lincinci.
Izazinzulu zihlole i-hypothesis yayo ngokubekwa kwinkcubeko yeeseli zomhlaza kumachiza ahlukeneyo. Ngamanye amaxesha, amayeza, ukuba indlela yesenzo sabo ichaphazele iinkqubo ezenzeka kwindawo yolawulo, icinezele ngempumelelo icandelo leeseli ezimbi. Ababhali besi sifundo banethemba elinothemba kakhulu kwaye bathe xhaba ukuvela kuvavanyo kwiinkcubeko zeseli ukuze basebenze nezilwanyana ezimodeli. Kuyimfuneko ukukhangela ukuba ungayihlasela njani le "Achilles Heels" yomhlaza kwizicubu. Kusekuqaleni kakhulu ukuba bathethe ngokuphuhliswa kweziyobisi ezigcweleyo kunye nesiphumo esifanayo, kodwa amachiza akhethekileyo sele evavanywa, ngokuyinxenye okanye ejolise kwi-SAC yophula umthetho we-SAC.
Ke umsebenzi omkhulu uya kuba yinto engenakwenzeka ngaphandle kwentsebenziswano ebanzi yamanye amazwe. Ababhali bofundo ziingcali kwilebhu yaseBona Ravid kwi-Sakler ye-Sakler kwiYunivesithi yaseTel Aviv University. Yancedwa yi-American Socies kwiziko elibanzi le-tun kunye ne-harvard (i-italied ye-getarserd), i-tu ye-vemont), i-Italierlautrn ye-European (i-Italis), njengoko Nokia therlands abaphandi kwiYunivesithi yaseGronen (kwiYunivesithi yaseGronen). Lilonke, iinzululwazi ezingama-26 ezipapashwa kubabhali belo nqaku zipapashwe kwijenali yontanga. Kwaye, ukugweba ngomthamo womsebenzi owenziweyo, akunjalo nakanye xa "ishawa elifileyo elilungele ukupheliswa okanye umsebenzi.
Umthombo: Inzululwazi yezeSwaziya