Idatha entsha yeSayensi i-Tsu iza kunceda ekuvavanyeni izigulana ngokubetha

Idatha entsha yeSayensi i-Tsu iza kunceda ekuvavanyeni izigulana ngokubetha

Iziphumo zophando zipapashwa kwi-upech yejenali yejenali yeWebhu yeHlabathi yeMolekshini. Injongo yophando olwenziwe ziingcali ze-neurobiologists ngenkxaso ye-RNF yayikukufundisisa inkqubo yokwenziwa kwee-neurons ezintsha kunye ne-ischemic strooke. Ukwenza oku, indlela entsha yokumakisha ii-neurons ezincinci zenziwa.

I-STU isayensi kunye noogxa bakhe kwiDyunivesithi yaseLövene (i-Belgium) yenze "ikhuriya" yokuhambisa izinto zemfuza kwiiseli zengqondo kwiileyile kunye neentsholongwane ezikhethekileyo. Indlela efanayo yokuhambisa izinto zemfuza ngoku isetyenziswa xa kusenziwa izitofu kunye neziyobisi.

Iinjineli zemfuza zifakwe kwintsholongwane yeprojekti yeProtein yeProtein kunye nolandelelwano olukhethekileyo lwemfuza ezikuvumela ukuba unyuse imveliso ye-Ferrin kuphela kwii-neurons ezincinci kuphela. I-neurons ezincinci ezaziqokelela i-Ferrin eziqokelelene iiatom zentsimbi zinokubona "zibona" ​​xa usebenzisa umthetho owodwa weMT.

Ukunqunyulwa kwengqondo, ipeyintwe zii-antibodies ukuya kwi-Ferritin Ferritine (ebomvu) kunye nemakisha ye-CD68 Macrophages (iluhlaza), kunye nomfanekiso wengqondo yesilwanyana esifanayo. Iintolo eziphawulwe kwiindawo zamaqela eeseli eziqokelelwe i-Ferrine, kunye ne-macrophas / © ifoto evela kwindawo yokugcina ilabhoratri ye-neurobiogy su

"Xa skikushekisi isilwanyana sengqondo, esasisondela e-Ischemic strooke, sabona iindawo ezimbini ngotshintsho oluthile kumqondiso omkhulu, libonisa ubukho belebhu enkulu ye-BB Tsurina khonavich . -Umqondiso wabhalwa kwindawo engeyiyo yomda, apho, emva kokubetha, ukuphuculwa okusebenzayo kwee-neurons ezincinci zihlala ziqala. Oku akumangalisi thina, kodwa ubukho bophawu olufanayo ekugxilwe kuyo ekugxilwesweni kweStroke yavela ukuba ingalindelekanga. "

Ukufundisisa okulandelayo kwamacandelo obuchopho abonise ukuba umqondiso onjalo ubonelelwe zii-macrophages - iiseli zenkqubo yomzimba, ebizwa ngokuba "yinqanaba elikhulu" (ukusuka kwelinye iBanga ")." I-Macrophages iyakwazi ukufaka idatha kunye nokugaya intsholongwane, i-Alien okanye ityhefu enetyhefu kunye neziqwengana zeeseli ezifileyo. Emva kokubetha kwengqondo, i-macrophas ifudukela kugxile kwi-ischemic kugxilwe kuyo, apho kungekuphela nje izicubu ezitshabalalayo zithatyathwa, kodwa neeseli ezibomvu zegazi zityebile kwinsimbi, ngaloo ndlela ukuba "zibonakale" kwi-MRI.

Iiseli eziqokelelwe i-iron kunye ne-ferrine isuswe ngokukhuseleka kakhulu. Umqolo ophezulu - I-InUNoohasical Stainsing yeFerrin (Ferrh), i-Neuron Makiskers (Neun) kunye neMacrophas (CD68). Uluhlu olusezantsi-Ipeyinti ye-probs kwi-PERS kwi-Iron / © Iifoto ezivela kwindawo yokugcina ilabhoratri ye-neurobiogy su

Ngokutsho kwe-neurobiologists, i-surobiogists, i-Tsu, ukubonwa kweqela lezahlulo kusetyenziswa i-MRI inokusetyenziselwa ukwenza indlela entsha yokuxilonga, eya kuba luncedo koogqirha basekliniki. Itekhnoloji iya kuvumela ukuvavanya ubunzulu bokuxinana kugxile ekugxilwesweni, ukufumana ulwazi oluthe kratya malunga nombuso wesigulana, ngokuchanekileyo uxele kwangaphambili ikhosi yesi sifo kwaye ukhethe unyango lweziyobisi.

Ngoku owona msebenzi uphambili kufuneka usombulule oochwephesha be-neurossologists kukufumana indlela yokwahlula imiqondiso evela kwi-macrophas kunye ne-neurons entsha ngeelebheli zemfuza. Ngenxa yoku, kuyimfuneko ukuqhubeka nezifundo eziqalile ukuze ufumane ulwazi olutsha olusisiseko malunga nokuziphatha kweMacrophages kunye ne-neurons entsha kugxininiso lwe-ISChemic ukoyisa. Kwimeko yokwandisa i-Grant RNF, iprojekthi entsha ye-SUSASESS iyakujolisa ekusombululeni le misebenzi.

Umthombo: Inzululwazi yezeSwaziya