I-Acetate - ethanol metabolite, eveliswa yi-Aldh2 enzyme. Isebenzisana ne-gamma-amine acid (gamc) - i-brake neurodiator yenkqubo ye-nervous system. Unoxanduva lokuba umntu onxilayo uziphatha njani. Umzekelo, abantu abatyatyamba botywala baqwalaselwe ukusilela kwe-Aldh2. Ke abanakuze babonakalise ngokukhawuleza i-cacetate.
Kwangoko yayikholelwa ukuba i-ethanol ye-ethalol yenzeka kwisibindi, kwaye sele kukho iimveliso zokuboleka kwingqondo. Nangona kunjalo, iqela lamaziko e-neurobologists yaseMelika evela kwiZiko leSizwe leSizwe le-US lezempilo ifumanise ukuba i-oxidation yenzeka kwingqondo. Iphelile, ibonakalisiwe kwi-Cerebellam ivule kwaye ibangela ilahleko yolungelelwaniso. Iinkcukacha zokuvulwa zipapashwa kwijenali ye-metabolism.
Izazinzulu zaphanda intetho ye-MRNA Aldh2 kwiindawo ezahlukeneyo zengqondo kumacandelo ali-11 eegubo zengqondo kunye nezicubu ezithathu zengqondo. Kwavela ukuba eyona ntetho ibonakalisiwe kwi-cerebellum, kwaye ubuncinci kwi-rust engaphambi koko.
Kwakhona, iqela lenze uvavanyo kwiimpuku. Kule, izazinzulu zazisa iintonga, ekungabikho kwengqondo yakhe i-Aldh2. Emva koko bona kunye nezilwanyana eziqhelekileyo banikwa inani elincinci le-ethanol (igram enye ngekhilogramu yesisindo). Ngexesha lohlalutyo, kuye kwavela ukuba utywala buvuselela imbonakalo ye-cerebell. Nangona kunjalo, iimpuku ezithathiweyo ziguqukele zixhathise ngakumbi kwimiphumo yotywala, kuba i-enzyme iphantse ingaguquki i-acetate, eqokelelweyo kwingqondo. Kwintonga ngaphandle kwe-asth2, bekukho nenqanaba elisezantsi lelitye kwingqondo emva kokusetyenziswa kotywala. Yiyo loo nto inguqulelo efanelekileyo.
Kwimpuku ngokunqongophala kwe-enzyme kwisibindi, ukuxhomekeka okunjalo kwaqwalaselwa. Oku kwavumela ababhali besifundo ukuba bacinge ukuba umthombo we-acetate kwi-cerebellum-utywala, hayi i-Aldehyde. Kodwa kuya kufuneka ibonakalise.
Okokugqibela, izazinzulu zafikelela kwisigqibo sokuba i-Aldh2 i-Enzyme, ezikwisibindi kunye nengqondo, ichaphazela umzimba ngeendlela ezahlukeneyo. Bazimisele ukuqhubeka nokufunda kwale i-enzyme ebantwini. Kwakhona, iingcali zibizwa ngokuba yi-Aldh2 i-Aldh2 ijolise ekunciphiseni isiyobisi kunye nezifo ze-neurological.
Umthombo: Inzululwazi yezeSwaziya