I-Acute Aleloid Leukemia (oml) iyi-turout ebabazekayo ye-Aleloid yegazi - ibhekwa njengezibulalayo kunazo zonke izinhlobo zomdlavuza wegazi, zibulala iziguli ezine zeminyaka emihlanu. Yize cishe ama-70-80% eziguli ezine-oml engaphansi kweminyaka engama-60 zifinyelela ukuzoxolelwa okugcwele okugcwele, abaningi ekuphindeni kwezokuxhumana kwenzeke kakhulu "indlela yokuthola imfihlo."
Eminye yemibono ethandwayo namuhla, ngoba akuwona wonke amangqamuzana esiminyanisi afana neleveli yofuzo (okungukuthi, i-heterogeneous), ezinye zazo zingamelana nokwelashwa, zibangele ukukhula okuphindaphindwayo. Omunye umbono uthi: Ukuphinda kwenzeka ngesikhathi se-leukemia ngenxa yokungamelana nezidakamizwa ekungenisweni kwezidakamizwa kwamaseli we-stem angaguqula isimila. Ngakho-ke, ngokusho kokubona, kusemangqangeni e-Iml nge-ImmunoneEnotype ye-ImmunoneERure (CD34 +, CD38-) I-Chemotherapy - ukusetshenziswa kwezidakamizwa ezinobuthi - Ukusetshenziswa kwe-chemotherapy zona. Kodwa-ke, ezinye izifundo zakamuva zikhombisile ukuthi ezinye izinto zinesibopho sokuphindaphinda nokungavikeleki ku-chemotherapy.
Ukuthola ukuthi kungani i-IML ibuya ngemuva kokwelashwa, ososayensi bazamile e-University of Virginia, Medical College wile, iHarvard Medical School (USA), University of Pennsylvania kanye ne-Cancer Biology Center e-University of South I-Australia. Iziphetho zabo zingatholakala ekushicilelweni komagazini wokutholwa komdlavuza.
"I-acute aleloid leukemia ingangena esigabeni sokuxolelwa usebenzisa i-chemotherapy, kepha cishe ibuya njalo. Lapho lokhu kwenzeka, lesi sifo asinakuphulukiswa, "kusho uDkt Ari M. Melnik, uprofesa weHematolology kanye ne-Oncology yezokwelapha. - Umbuzo wakudala kule ndawo uzwakala kanjena: "Kungani ungakwazi ukuqeda wonke amaseli womdlavuza?" Umbuzo ofanayo ungasetwa kumongo wezinye izinhlobo zomdlavuza onolaka, ngaphezu kwe-IML.
Lolu cwaningo lwenziwe zombili kuma-othoids nakwithuli laselebhu, elakhulisela amaseli umdlavuza. Imiphumela yaphinde yaqinisekiswa kumasampula athathwe ezigulini ezine-acute aleloid leukemia ngesikhathi sokwelashwa nangesikhathi sokuphindeka. Njengoba ososayensi bathola ukuthi amaseli we-leukemia afakwa ngaphansi kwama-chemotherapy, ingxenye yabo yadlula ekugugeni ngezimpawu zokuthola amanxeba okuphulukisa asheshisiwe, yaphenduka iningi lemisebenzi yalo futhi laheha amaseli omzimba ukuba alulame.
Ukucindezelwa kwe-geotoxic okubangelwa i-chemotherapy, ngaphezu kwe-apoptosis, ukugqugquzela ukuguga - ukusabela okucindezelayo kweseli kubonakaliswa ngumsebenzi we-metabolic ngokungabikhona. Ukushintshela "kwimodi yokulala" kuvunyelwe amaseli esimila ukuze asinde kulokhu: Ngenxa ye-phenotype yokumelana nokuguga. Ngokusho kososayensi, umphumela wokuguga wawungowesikhashana futhi wanikeza ithuba elihle kakhulu lokwakheka kwamakoloni, futhi ngemuva kokululama kweseli le-oml elibangele ukuphindeka ngekhono elikhuphukayo lamaseli we-stem.
"Lokhu kuvame ukubonwa kusuka ekuthuthukiseni umbungu okuvimba okwesikhashana ukukhula kwawo ngenxa yokuntuleka kokudla. Inhlanhla enjalo ibizwa nangokuthi i-Embucronic Diapause, - Kungezwe uMelnik. - Le akuyona inqubo ekhethekile, kepha umsebenzi ojwayelekile wezinto eziphilayo, ezibonisa ngokwaso ngomongo wamathumba. "
Izifundo zocwaningo zibuye zathola ukuthi isimo sokuguga kanye namangqamuzana e-tumor esitokisini se-tumor kudala amaprotheni e-ATR (i-serin / treoninic artr ProteinAxinase, kwaziwa njengeProtein ehlobene ne-RAP3 noma amaprotheni ahlobene ne-Frap 1 (Frp1)). Okungukuthi, kunengqondo ukuvimba i-atr ukuze amaseli omdlavuza awaweli emfingweni. Ngemuva kokuhlolwa kwelebhu, ososayensi bakuqinisekisile ukuthi ukwethulwa kwe-inhibetor yale protein - Ve821 - amahora angama-24 ngaphambi kokuthola ukwethulwa kwemodi yokulala nokuguga, ngaleyo ndlela kukuvumele ukubulala wonke amaseli we-tumor.
Manje ososayensi basebenza nezinkampani - abakhiqizi be-Artr inhibitors. Kuyiqiniso, kusafanele ukuphendule imibuzo yokuthi ukwelashwa okunjalo kufanele kunqunywe nini futhi kanjani. Kodwa-ke, ezinye izifundo ezifanayo sezikhombisile ukuthi isimo sokuguga kanye ne- "hibernation" kubalulekile hhayi kuphela kumongo we-leukemia omkhulu, kodwa futhi neziguli ezinomdlavuza webele ojwayelekile, i-prostate noma isisu.
Umthombo: Isayensi Enqunu