Isifo sobuchopho kunzima ukwelapha hhayi kuphela ngoba kuyisitho esiyinkimbinkimbi kakhulu somzimba wethu. Futhi kuvikelwe kakhulu: noma imithambo yegazi ayihlotshaniswa nezicubu zohlelo lwezinzwa oluphakathi, oluhlukanisa namaseli wesithiyo se-hematostephalic. Ukugcwaliseka kwe-BGB kukhethiwe: umoya-mpilo kanye nezakhi zomzimba ezidlula kuzo, kepha akuphuthelwa ubuthi, amagciwane namanye ama-ejenti angaba yingozi. Kodwa-ke, akuvumeli ukufika ebuchosheni kanye nezinto ezahlukahlukene ezinenzuzo.
Akumangazi ukuthi ososayensi bamazwe ahlukene bazama ukudala izindlela zokunqoba i-BBB: Isibonelo, ama-nanoparticles angenalutho angangena emangqamuzaneni obuchopho, akhulule umuthi ngaphakathi futhi akhulule asevele ekhona. Futhi iqembu leZhiganana (Zhiguang Wu) elivela eHarbin University liqoqe le microbot yonke. Babekhuluma ngokuthuthuka kwabo esihlokweni esishicilelwe kumagazini weSayensi ama-Robotic.
Ososayensi babiza uhlelo ngokuthi "uNeutrobot", ngoba umhlangano, izingcezwana zama-neutrophils, kusetshenziswa amaseli egazi ama-imzimba. Kwenzeka ngale ndlela elandelayo. Ekuqaleni, ababhali balungiselela izinhlayiya ezinobunzima be-microscopic kanye ne-magnetic nangel ": Uhlaka lwe-polymer, olunezindawo ezibucayi, lungathola inani lamanzi, lingathola imali eningi kanye nomuthi odingekayo. Ngokulandelayo, amaseli ama-bacteriya ezinduku zamathumbu abulawa futhi "akhutshiwe", asuse konke kakhulu futhi ashiya izingcezwana zomelweli weseli. Bamboze izinhlayiya ze-gel.
Ukuvikelwa kwegciwane le-bacterial membrane "njenge-rag ebomvu." Ngakho-ke, lapho izinhlayiya ezilungiselelwe zazixutshwa nama-neutrophils, zisheshe zihlasele futhi zenziwa i-phagocytosis, zithola into engenzeka ingozi. Ngenxa yezakhiwo zamazibuthe ze-nangel, ukunyakaza kwazo kungalawulwa ngokuthinta amandla kazibuthe angaphandle ukuqondisa amaseli ebuchosheni. Ngokusebenzisa ama-neutrophils we-BC ayakwazi ukudlula kalula nangokuzimela, ukuheha amasiginali wokuvuvukala kusuka ebuchosheni beziguli. Nawe, baphatha kanye nemithwalo yezidakamizwa ewusizo.
Ukusebenza kwesayensi "yabo" yabo "kuboniswe hhayi kuphela" kushubhu lokuhlola ", kodwa futhi nasegunjini lokuhlalisa ilabhorethri - umugqa oyimodeli, osetshenziselwa izifundo ze-Gyoma, ama-fumors obuchopho. Izinhlayiya ze-Nangel zazilayishwe yi-anticancer zilungiselela i-paklitaxel, zibekwe ezinhlakeni zamagciwane nama-neutrophils, bese zivele zenziwe "neutrobots" zifakwe emthanjeni womsila. Maduze nje kwasuswa ukuthi lezo zinqobile ngempela i-BC futhi zilethe umuthi ezicutshini zohlelo lwezinzwa oluphakathi.
Manje ababhali bahlela ukwenza ukucolisiswa kanye nokwenza ngcono uhlelo lwabo. Okokuqala, ososayensi banentshisekelo kwinqubo yokuphatha ukunyakaza kwe- "Neutrobots" nokulawula ukunyakaza kwabo. Ngenkathi amandla kazibuthe esebenza kabanzi, eqondisa ngasohlangothini olifunayo lonke inqwaba yezinhlelo ezinjalo microscopic futhi alahlekelwe izinhlayiya eziningi eceleni komgwaqo.
Umthombo: Isayensi Enqunu