Umphintu we-Universal, okwazi ukuvikela umuntu kwa-SARS-Cov-2 Virus, "izihlobo" zakhe nezihlobo zakhe ezingaba khona

Umphintu we-Universal, okwazi ukuvikela umuntu kwa-SARS-Cov-2 Virus, "izihlobo" zakhe nezihlobo zakhe ezingaba khona

I-antibody Antibody Adg-2 isungule iqembu lochwepheshe ezikhungweni ezimbalwa zocwaningo lwase-US, izinhlangano ezingenzi nzuzo kanye nezinkampani ezimbili ze-biotechnological. Imiphumela yososayensi bawo umsebenzi bashicilele kwi-Journal Review Science American Association yokuthuthukiswa kwesayensi (AAAS).

Naphezu kwezimpumelelo ezihlaba umxhwele ekwakheni imigomo eyakha ukungavikeleki eCoronavirus SARS-Cov-2, umenzeli we-cavid-19 wesikhathi eside, ukusebenza kwawo kwesikhathi eside kusangabazekayo. Hhayi kakhulu ngenxa yokushiyeka kwezidakamizwa ngokwabo, njengoba nje amandla amagciwane asheshe aguquka ngokushesha kakhulu. Ngaphezu kwalokho, iningi elivunyiwe futhi lisetshenziselwa ukufundwa kokugoma kuphela njengelitshe lengxenye efanayo ye-virion.

I-Antibody Adg-2, enamathiselwe kubhekele ukunamathisela esitokisini esiqondiwe yisizinda kwi-SARS-CoV-2 Virus Calxide. I-microfotography eyenziwe yi-microscopy ye-cryoelectronic / i-microscopy ebanzi nenamandla ngokumelene namagciwane afana ne-SARS yi-monoclonal antilody antibody, C. Garrett RapPazzo et al., I-EABF4830: 10.11126 / Science.abf4830

Sikhuluma ngezinhlaka ezikhethekile egobolondweni leViral Capsid, elibhekele ukunamathisela iseli elinegciwane - isizinda sokubopha iRector (RBD). Lezi zindawo zingaphansi kokuguqulwa njalo futhi zingahlukahluka kakhulu phakathi kwezinhlobonhlobo zegciwane elilodwa, hhayi ukusho izinhlobo ezihlobene. Ngakho-ke, abaphenyi baseMelika bagxile emizamweni yabo ekwakheni amasosha omzimba angahle aguquguquke ngokwengeziwe.

Ama-ejenti anjalo abizwa ngokuthi ama-antibodies abanzi abanzi (ama-antibodies abanzi, ama-antibodies abanzi, ama-BNABS) futhi angaba yisisekelo semijovo yendawo yonke ekwazi ukuvikela ngokushesha emndenini wonke wamagciwane. Futhi ngocwaningo olude, kungenzeka ukuthi kwakha abantu abaningana: ADG-1, ADG-2 ne-ADG-3. Njengomphumela wokukhethwa, ukuxhumana nekhodi ye-ADG-2 bekuyimpumelelo kakhulu.

I-Modeling Adg-2 Esakhiweni / umsebenzi obanzi futhi onamandla ngokumelene namagciwane afana ne-SARS yi-Excured Human Antilody Antilody, C. Garrett RapPazzo et al., Isayensi 25 Jan 2021: I-EABF4830: I-EABF4830: I-SEBF4830

Amandla awo okuhlasela eCoronavirus ahlolwe esikweni lamaseli egundane, futhi kuyamangaza. I-ADG-2 ixhumeka ngokuphumelelayo kokuhlukahluka okuphezulu kweshumi nambili kwe-SARS-FOCK-2-2, manje esesabise ubuntu. Ososayensi babone indikimba ethembisa ama-magciwane ezinhlobonhlobo ezahlukahlukene, lapho i-RBD ihluke kakhulu. Yini ethakazelisa kakhulu, i-ADG-2 ikhombisa amandla aphezulu okunamathisela "izihlobo" ezahlukahlukene zemithambo ye-Covid-19 - amagciwane aphansi weSarbecovirus.

Umthombo: Isayensi Enqunu