Imiphumela yocwaningo ishicilelwa ku-Journal Analytical Chemistry. Ukulungiswa okuphezulu okuphezulu kwe-spectrometry kuyindlela yokuhlaziya izidakamizwa esekelwe ekulinganiseni okunembile kwesilinganiso sesisindo sokushaja (m / z) ama-molecule e-iones kanye nokuqina kwesiginali ehambelana nabo (inani elihlobene). Lolu lwazi likuvumela ukuthi unqume isisindo samangqamuzana amakhompiyutha, isakhiwo sawo, esisiza ukubona amaprokhi, njengamaprotheni, ama-lipid, ama-peptides, izingxenye zezidakamizwa nezinye izinto.
I-Mass Spectrometric EmiJing (MCI) ikuvumela ukuthi uthole imininingwane ekusatshalalisweni kwendawo kuma-molecule ezicubu, ekuhlaziyeni okuningi kwe-Ions e-Iolecule yendawo ngayinye yesampula ngaphansi kocwaningo (ngokwesibonelo).
Ukuhunyushwa kwedatha ye-MSI kungumsebenzi onzima. Ekuqaleni, kuyadingeka ukubona ngeso lengqondo ukusatshalaliswa kwama-ion phezu komhlaba we-cutofving tessus, okungukuthi, ukwakha isithombe esijwayelekile sombala, lapho indawo ngayinye inombala wayo ofanayo - ihambelana nombala wayo. Kusukela ezinkulungwaneni zama-ion ngephuzu ngalinye udinga ukuya kumanani amathathu amancane okufanele ahloniphe idatha ye-MSI ngokugcwele futhi engaxhunyaniswa nendawo enezici ezinemibala emithathu ngokuhlaziywa kwayo okulandelayo.
"Kubalulekile ukukhulisa okuqukethwe kolwazi kwesithombe esiphumela, kuyadingeka ukubheka izici zombono womuntu, ikakhulukazi, ukuzwela kwayo nokuzwela okuhlukile kokushintsha kokukhanya nokukhanya kwe-Chroma.
Futhi, yize inkolelo-mbono yokuqonda imibala ihlolwa isikhathi eside (kusukela engxenyeni yokuqala yekhulu lama-20), ngisho naphakathi kochwepheshe Awekho amamodeli wezibalo amukelwa ngokuvamile, echaza kahle zonke izakhiwo ezaziwayo zombono womuntu , "Umbhali wokuqala wesifundo, othweswe iziqu syoltech anastasia sarychev uthi.
Abaphenyi abavela enkabeni yesayensi nobunjiniyela bezobuchwepheshe be-computer enemisebenzi emikhulu yedatha (cdise) kanye nelebhu ye-Visual Spli RAS banikeze indlela entsha yokubona idatha ye-MSI, kodwa ephansi ngasikhathi sinye ngokususelwa emcabangweni wokubona kombala womuntu.
Indlela entsha igcina imingcele kanye nama-gradients lapho usebenzisa izindawo ezikhethiwe zokwakheka okufanayo kwe-ionic. Ngobuhle kwalokhu, isithombe esivelayo sihunyushwa lula ukwedlula kwezinye izindlela zokucabanga kwedatha ye-MSI. Le ndlela ihlolwe zombili kumodeli kanye nedatha yokuhlola etholwe ngabacwaningi belebhu ye-mass spectrometry ye-skolteha kanye nezazi zezinto eziphilayo ze-neurobiology kanye ne-neuroability of Scothech.
Umthombo: Isayensi Enqunu