I-Acetate - I-Ethanol Metabolite, ekhiqizwa yi-Enzyme ye-Aldh2. Isebenzisana ne-Gamma-Amine Oud Acid (Gamc) - I-Brake Neuromediator yohlelo lwezinzwa oluphakathi. Unesibopho sokuthi indoda edakiwe iziphatha kanjani. Isibonelo, abantu abaqhakaza ngotshwala babonwa ngokushoda kwe-ALDH2. Ngakho-ke ngeke bakwazi ukukhiqiza ngokushesha i-acetate.
Phambilini kukholakala ukuthi i-ethabolism ye-ethanol yenzeka esibindini, futhi bekuvele kukhona imikhiqizo ebolile ebuchosheni. Kodwa-ke, iqembu le-American Neurobogists elivela esikhungweni sokuba izikhungo zika-Alcoholism National Institutes of US Health bathola ukuthi i-oxidation ye-acetate ingenzeka ebuchosheni. Kwavela, kuvezwa kuma-astrebellum astrocytes futhi kubangele ukulahleka kokuxhumana. Imininingwane yokuvulwa kwanyatheliswa ejeni yemvelo Metabolism.
Ososayensi baphenya isisho seMnu Aldh2 ezindaweni ezahlukahlukene zobuchopho ezigabeni eziyi-11 zezicubu ze-mouse zobuchopho nezingxenye ezintathu zezicubu zobuchopho bomuntu. Kwavela ukuthi inkulumo enkulu ivezwa ku-cerebellum, futhi okungenani ku-crust overbontal.
Futhi, iqembu lenze isivivinyo kumagundane. Kulokhu, ososayensi balethe amagundane, ubuchopho bakhe kwakungeyona i-Endh2 enzyme. Ngemuva kwalokho kanye nezilwane ezijwayelekile zanikezwa inani elincane le-ethanol (i-gram eyodwa ngekhilogremu yesisindo). Ngesikhathi sokuhlaziywa, kwavela ukuthi utshwala buvuselela ukubukeka kwe-acetate ku-cerebellum. Kodwa-ke, amagundane athathwe atholakele avumelanise kakhulu nemiphumela yotshwala, ngoba i-enzyme cishe ayizange iguqukele utshwala ibe yi-acetate, eqongelelwa ebuchosheni. Egunjini ngaphandle kwe-Astrocytic Aldh2, futhi kwakukhona nezinga eliphansi le-gamke ebuchosheni ngemuva kokuphuza utshwala. Ngakho-ke ukuxhumana okuhle kakhulu.
Egunjini nokushoda kwe-enzyme esibindini, kwaqanjwa ukuncika. Lokhu kwavumela abalobi bocwaningo ukuthi bacabange ukuthi umthombo we-acetate ku-cerebellum - utshwala, hhayi u-Aldehyde. Kepha kusafanele ukufakazele.
Ekugcineni, ososayensi bafinyelela esiphethweni sokuthi i-Endh2 Enzyme, esesigabeni nasebuchosheni, kuthinta umzimba ngezindlela ezihlukile. Bahlose ukuqhubeka nokutadisha kwaleli enzyme ebantwini. Futhi, ochwepheshe ababizwa nge-Astrocital Aldh2 ilitshe elibalulekile ekwelapheni umlutha wotshwala nezifo zezinzwa.
Umthombo: Isayensi Enqunu