Amathumba amhlaza ayakwazi ukufudukela "kwimodi yokulala" ukujongana ne-chemotherapy

Ukusebenza kweHibernation esebenzayo kunceda iiseli zendlela yokusebenza engafanelekanga ukuze kugxilwe kuxinzelelo kunyango lwenkcitho

Abasebenzi beeyunivesithi ezininzi zase-US kunye ne-Australia bafumanisa ukuba utshintsho "kwimodi yokulala" ivumela iiseli zomhlaza ukuba zinamava e-chemotherapy. Inkqubo enjalo kwixesha elizayo inokukhokelela ekufumanekeni kwemfundo engafunekiyo. Izinto zophando zapapashwa kwimagazini yokufumana umhlaza.

I-abute myloid leukemia inokuya kwi-gomothemia inyanga, kodwa ihlala ibuya ibuya. Xa oku kusenzeka, esi sifo asinyangeki. Umbuzo wexesha elide kule ndawo ivakala ngolu hlobo: "Kutheni le nto ungazikhupheli zonke iiseli zomhlaza?" Umbuzo ofanayo unokubuzwa kwimeko yezinye iintlobo zomhlaza onoburharha, ukongeza kwi-IML. - I-Ari M. Melnik, Gqirha, uNjingalwazi we-hematology kunye nonyango lonyango.

Njengenxalenye yesifundo, uthotho lweemvavanyo kwii-organoids, kunye neempuku zelebhu, umzimba okhuliswe ziiseli zomhlaza. Ngapha koko, iziphumo ziqinisekisiwe ziisampulu ezikhethwe kwizigulana ezinemo efihlakeleyo ye-IML ngexesha lonyango emva kokuphinda-phinda isifo. Kwafunyaniswa ukuba iiseli ze-leukemia ngexesha le-chemotherapy zifudukele kwimeko yokuguga kunye nemiqondiso "yeHibernation esebenzayo". Kwimeko enjalo, babonakala eyonakalisiweyo kwaye kufuneka babuyisele. Ukucofa uninzi lwemisebenzi yayo, baqhagamshela iiseli zokuziqhelanisa nokuphiliswa.

Inguqu enjalo "kwimodi yokulala" yaqinisekisa ukusinda kweeseli zomhlaza ezivela kwi-gemoto pheshey evela kwi-chemotherapy. Emva kokuvuka eziseleni zinokunikwa iikholoniya ezintsha zomhlaza ngendawo eyandayo yeeseli zesiqu. Ngokutsho kukaMelnik, inkqubo efanayo ibiye yaqatshelwa kwimibungu, enokuthi iyeke okwethutyana ukukhula ngexesha lokutya okungonelanga. Inkqubo ye-stornic diypause yinkalo yendalo yendalo, ibonakaliswe kwimeko ye-tument yamathumba.

Izazinzulu zachaza ukuba inkqubo yenguqu kwi "Mode yokulala" kwiiseli zomhlaza zihambelana neprotein ekhethekileyo. Kuxelwe ukuba okwangoku abaphandi basebenzisana kunye neenkampani ezibandakanyeka ekuvelisweni kwezithintelo ze-protein. Oku kuyakuvumela kwixesha elizayo ukuphucula amachiza kungekuphela nje kwizigulana ezinomvuzo ophindaphindiweyo, kodwa nomhlaza wamabele.