Lefatšeng la likokoana-hloko, likokoana-hloko tse ngata kapa lithakomere tse ngata li ka phela ka bo bona ntle le ho tšoaetsa lisele tse rekisang. Empa livaerase ha li khone. Ho fapana le moo, ba tlameha ho kena lisele tse ngata tse ngata, moo ba sebelisang mokhoa oa bona oa bocha ea biochemical ho theha likaroloana tse ncha tsa vaerase le batho ka bomong. Joalo ka bophelo bohle, li-coronavisuse ka boeona li pota-potiloe ke khetla e mafura. Ho kenella ka lisele, ba sebelisa liprotheine (kapa li-glycoproteins, joalo ka ha li koaheloa ka limolek'hule tsa tsoekere ka lebaka la memmbrane ka hona li hapa seleng. E 'ngoe ea li-glycoteinte tsena tsa vaerase ke protheine ea spike ea coronavisus. Ha a hlaha libaka tse ncha tsa coronaviruus Sronaviruus Sronaviruus Sronavirus Sroirrel ho ea sekhutlo sa spike se eketsehile haholo. E ile ea hatella likhetho tse ncha tse 19 Comment e nang le liphetoho tse kholo proprokehi tsa sepekere ha li bapisoang le likhetho tse ling tse haufi.
Li-spikes liprotheine
E 'ngoe ea litšobotsi tsa tlhaho tsa coronaviruus Sronaviruus Sronaviruus Sronavirus Sronaviruus hammoho le vaerase tse ling, na ho ba teng ha li-vaerate tse ling, na ho ba teng ha li-vaerate tse ling tse lumellang likokoana-hloko tse lumellang likokoana-hloko ka lisele tse ling' me li baka ts'oaetso. Ha e le molao, vaerase sona ea boholo ba coronaiviruse e kenyelletsa protheine e meraro ea memmbrane (M), Shell Proptiin (e)
Thupelo ea inf e itihileng e na le li-amino acid tse 1160-1400, ho latela mofuta oa vaerase. Ha e bapisoa le liprotheine tsa M le e kenngoeng haholo kopanong ea vaerase, e leng litšoantšiso tsa bohlokoa ho penne ho kenella ka lisele tsa ho kenella ka har'a lisele. Hoa hlokomeleha hore ke boteng ba liprotheine tse ho Coronavirus ho lebisa ho methapo e bopehileng joaloka lihlomo.
Litsebi tsa naha ea Coronavirus li ka aroloa ka har'a lihlooho tse peli tsa bohlokoa tse sebetsang, tse kenyelletsang hlooho ea s1, 'me sebaka se sentsoeng ka kotloloho ka koranta e hahiloeng ka kotloloho ka shellsitle. Ha e sebelisana le sele e ka bang teng, sephutheloana sa s1 se tlamanting le ho tlatlapa karolo ea protheine e thata, eo e leng karolo ea turrase e nang le memmbrane .
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Hoa hlokomeleha hore ntle le li-vause tsa protheine joaloka Sors-COV-2, ha ho mohla li lilingoang tsa beng ba e-na le liphoofolo le batho. Ke ka lebaka lena la protheine e spen e ntle bakeng sa lipatlisiso tsa liente tsa ente le lithethefatsi tse thibelang. Ntle le karolo ea eona ka seleng, phathera ea s-virus, ka ho khetheha, ka ho khetheha, ke sethala se ka sehloohong sa li-antibodies tsa li-antibodies (NABS). Nabs ke li-antibodies tse sirelelitsoeng tseo ka tlhaho tsa tsamaiso ea rona ea 'mele.
Li-spikels le liente
Lisele tsa rona li bile teng ho bontša tlhaselo ea livaerase. E 'ngoe ea matla a mantlha a sekametseng ho bahlaseli a tsoang ho bahlaseli ke khetla e ntle e nang le lesela le nonneng le nang le li-enzyme, liprotheine le ho theha seleng. Ka lebaka la mofuta oa biochemical oa mafura, sebaka se ka ntle se senya livaerase tse lokelang ho hlola tšitiso ena ho fumana seleng.
Ho nahana ka profinko ea Spike ea Spike bakeng sa vaerase ke hore, phello ea liente tse ngata tsa antiviral kapa lithethefatsi tse ngata tse ikemiselitseng glycoproteins. Liente khahlanong le Sars-CV-2, e hlahisoang ke Pfizer / Bionatech le Redria System, e etsahalang haufinyane ka mor'a thibelo. Ho hlahisoa ha prothele ea Spike ka hare ho lisele tsa rona e rarolla tlhahiso ea lisele tsa li-antibodies tse sirelelitsang le lisetlelong tsa TR.
Vaetlo e bakang feberu e le 'ngoe ea spike e le' ngoe ea spike protein, e le vaerase ea ntaramane e na le tse peli, 'me vaerase ke herpes e bonolo - metso e mehlano.
Joalokaha puisano e ngola, e 'ngoe ea lintlha tsa bohlokoahali tsa protheine ea Li-SV-2 ke kamoo ho tsamaeang ka eona kapa liphetoho ka nako e telele nakong ea ho iphetola ha lintho tsa bohlokoa tsa vaerase. Liprotheine e kentsoeng ka tatellano ea vaeral e ka ntlafatsa le ho fetola thepa ea eona ea bo-biochemical joalo ka ha ho hlaha ha vaerase.
Liphetoho tse ngata ha li rue molemo ebile li emisa ts'ebetso ea protheine ea spike, kapa ha e ame tšebetso ea eona. Empa ba bang ba bona ba ka baka liphetoho tse fanang ka mofuta o mocha oa vaerase e etsang hore e feteletsoe kapa e tšoaetsoe haholoanyane. O mong oa litsela tseo sena se ka etsahalang ke phetoho karolong ea squirrel ea spike e thibelang ho tlatlapa ha li-antibodies tse sireletsang tse nang le eona. Mokhoa o mong ke ho etsa hore li-spikes "li hlophisehile haholoanyane" bakeng sa lisele tsa rona.
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Ke ka lebaka leo liphetoho tse ncha tse fetolang mesebetsi ea squirrel kapa protheine e na le ho ameha ka ho khetheha - li ka ama tsela eo re tsamaisang ka eona-cov-2. Mekhoa e Ncha Haufinyane tjena Afrika Afrika le Afrika Boroa e na le liphetoho likarolong tsa protheine ea stend, ho nka karolo ho kena lisele tsa hau. Liteko tse ling tsa lipatlisiso le liteko tsa laboratori li tla thusa bo-ramahlale bona - le liphetoho tsena li fetohile haholo haholo, le hore na mehato ea rona ea taolo ea morao e sa sebetse.