ACUTE Myeloid LEUKEMIA (OML) iganda rakaipa remuziyo weropa Kunyangwe nezve 70-80% yevarwere vane oml pasi pemakore makumi matanhatu kusvika pakuregererwa kuzere, vazhinji mukudzokekurirana kunoitika kazhinji "nzira yakavanzika."
Imwe yemazano anozivikanwa nhasi ndezvekuti, sezvo zvisingaite ese masero emapundu akafanana pachiyero (kureva kuti, ndezvazvo), dzimwe dzadzo dzinogona kuramba kurapwa, zvichikonzera kukura kwakadzokorora. Imwe fungidziro inoti: Kudzokorora panguva yeLeukemia kunoitika nekuda kwezvinodhaka-zvinodhaka kusvika pakubata kwemasero emasumbu anogona kushandura bundu. Saka, maererano nekuona, iri mumasero eIML neyekupisa imba. + CD38 +, Cancer inokwanisa kupona, kunyangwe ichishandiswa kwezvinhu zvine chepfu chinodzora kudzidziswa kwe cancer cancer cancer ivo. Nekudaro, zvimwe zvidzidzo zvichangobva kuitika zvakaratidza kuti zvimwe zvinhu zvine mhosva zvakare nekudzokorora uye kudzivirirwa kumakemotherapy.
Kuti uwane kuti nei IML ichidzoka mushure mekurapwa, masayendisiti akaedza kubva kuYunivhoni yeVirginia, Harvard Kurapa Chasell, Harvard Medical Chasell, Harvey of Pennsylvania neCancer Biology Center kuYunivhesiti yeSouth Ositireriya. Mhedzisiro yavo inogona kuwanikwa mubhuku rekanza yekuwana chiratidzo magazini.
"ACUTE Myeloid Leukemia inogona kuenda mudanho rekuregererwa kushandisa chemotherapy, asi rinenge rinongodzoka. Kana izvi zvikaitika, chirwere chisingarapike, "akadaro Dr. Ar. Melnik, purofesa we hematology uye yekurapa oncology. - Mubvunzo wekare munharaunda ino wakanzwika sezvizvi: "Nei usingakwanisi kubvisa masero ese ekenza?" Mubvunzo wakafanana unogona kuiswa mumamiriro emamwe marudzi ekenza ine hutsinye, kuwedzera kune IML.
Chidzidzo ichi chakaitwa pane zvose zviri zviviri pamusoro pezvinyorwa uye pamakonzo emarabhoritari, ayo akasimudza cancer masero. Mhedzisiro yacho yakazvisimbiswawo mumatura yakatorwa kubva kune varwere vane acute myeloid leukemia panguva yekurapwa uye panguva yekudzoka. Semasayendisiti vakaziva kuti masero eReokomia akaiswa mumakemikari, chikamu chavo chakave nekukwegura nezviratidzo zve "zvakakundwa." Vakafunga kuti vakakurumidza kupora, vakadzima mabasa avo uye vakakwezva masero emagetsi ekupora.
Kushushikana kweJeopotherapy kunokonzerwa nemakemotherapy, kuwedzera kune apoptosis, zvinomutsa kukwezva - cell kushushikana maitiro anoratidzwa neAberran Metabolic chiitiko mukushaikwa kwehuwandu hwekuwedzera. Shanduko ye "Kurara Mode" akabvumira masero emucheka kuti apone izvi: Nekuda kweiyo phenotype yekupokana nekukwegura. Sekureva kwemasayendisiti, mhedzisiro yekukwegura yaive yenguva pfupi uye yakapa mukana wakanaka kwazvo wekuumbwa kwemakoloni, uye mushure mekupora kweiyo OML sero yakakonzera kudzokorora nekuwedzera kwemasero ematanda.
"Izvi zvinowanzotariswa kubva mukukudziridza migybo izvo zvinomisa kukura kwavo kwenguva pfupi nekuda kwekushaikwa kwehutano. Mari yakadaro inonziwo aumburyonic diapuse, - yakawedzera Melnik. - Ichi hachisi chiitiko chakakosha, asi zvakajairika zviitiko zvekubereka, izvo zvinoratidzira pachako mumataurire emamota. "
Zvidzidzo zvechidzidzo chakawanikwawo kuti mamiriro ekukwegura uye matope emakwenzi ari muTumor anokonzeresa protein (Serin / trininic terr protein (Frp1)). Ndokunge, zvine musoro kuvhara ATR kuitira kuti mashekero echigoma haawire muHibernation. Pashure pokuedzwa mumarabhoritari, masayendisiti akasimbisa kuti kuiswa kweiyo protein iyi - Ve821 - maawa makumi maviri nemana - Kuchembera, nokudaro achikubvuma kuuraya masero ese ematumba.
Iye zvino masayendisiti anoshanda nemakambani - vagadziri veATR inhibitors. Ehe, iyo ichiri kupindura mibvunzo nezve apo kurapwa kwakadii uye kuti kurapwa kwakadii kunofanira kutemwa. Nekudaro, zvimwe zvidzidzo zvakafanana zvakatoratidza kuti mamiriro ekukwegura uye "hibernation" yakakosha kwete chete mumamiriro egomarara remazamu, asiwo ane cancer yemazamu, prostate kana dumbu.
Kunobva: Naked Science