Acetate - ethanol metabolite, iyo inogadzirwa neALDH2 enzyme. Zvinotambudza neGamma-Amine Mafuta Acid (GAMC) - Iyo Brake Neuromediator yeCentral Nervous system. Iye ane basa rekuti murume akadhakwa sei. Semuenzaniso, vanhu vanokwira kubva padoro vanocherechedzwa kushomeka kweALDH2. Saka havagone kukurumidza kuburitsa acetate.
Pakutanga zvaitendwa kuti ethanol metabolism inoitika muchiropa, uye kwaive kwatova zvigadzirwa kuhuropi kuhuropi. Nekudaro, boka remabhuku eAmerica neurobhologists kubva kuInstitute yekudhakwa National Institutes yehutano hweUS akawana kuti oxidation yeacetate inogona kuitika muuropi. Izvo zvakazoitika, zvinoratidzwa muCeibellum nyeredzi uye zvinokonzera kurasikirwa kwekurongeka. Nhoroondo dzekuvhura dzinobudiswa mune chinyorwa chechinyakare metabolism.
Masayendisiti akaongorora kutaura kweiyo MrNA ALDH2 munzvimbo dzakasiyana siyana dzehuropi pane zvikamu 11 zvezvikamu zvebroubles uye zvikamu zvitatu zveuropi hwemunhu tishu. Izvo zvakazoitika kuti kutaura kwakawanda kunoratidzwa muCerebellum, uye diki mukupokana kwekutanga.
Zvakare, timu yakaita zvekuyedza makonzo. Kune izvi, masayendisiti akauya nemakonzo, muurouro hwaani hadzizi a aldh2 enzyme. Ipapo ivo uye mhuka dzakajairwa dzakapihwa hushoma hwethanol (imwe gramu pane kilogiramu yehuremu). Munguva yekuongorora, zvakazoitika kuti doro rinomutsa kutaridzika kwenyaya mune cerebellum. Nekudaro, iyo inotorwa mbeva yakazove yakangoita kuti ishandise zvakanyanya kune zvinokonzerwa nedoro, sezvo enzyme haina kutendeuka doro kuve acetate, iyo yakaunganidzwa muuropi. Mumakonzo pasina Astrocytic ALDh2, pakanga painewo chikamu chakaderera chegamaki muuropi mushure mekudhakwa. Nokudaro kurongeka kwakanyanya.
Mumakonzo nekushomeka kweiyo enzyme muchiropa, kuvimba kwakadaro kucherechedzwa. Izvi zvaibvumira vanyori vechidzidzo kuti vafunge kuti kunobva kwakaitwa nemhemberero - doro, uye kwete aldehyde. Asi icho chichine kuratidza.
Pakupedzisira, masayendisiti akauya kumhedziso yekuti enzyme enzyme, iri muchiropa uye uropi, hunokanganisa muviri munzira dzakasiyana. Ivo vanofunga kuti vaenderere mberi nekufunda kweiyi enzyme muvanhu. Zvakare, nyanzvi dzinodaidzwa kuti dentrocess aldh2 chinangwa chakakosha chekurapa kwekupindwa muropa nedoro uye nezvirwere zvechirwere.
Kunobva: Naked Science