Gutanga ikizere AntiB-2 byateje imbere itsinda ryinzobere mubigo byinshi byubushakashatsi, imiryango idaharanira inyungu hamwe nibigo bibiri bibaho. Ibisubizo by'umurimo wabo w'abahanga batangajwe mu ishyirahamwe risubirwamo ry'abanyamerika basubijwe mu iterambere rya siyansi (Aaas).
Nubwo ibyagezweho bitangaje mugushiraho inkingo zikora ubudahangarwa kuri coronavirus sars-cov-2, umukozi wa covidi-19, imikorere yabo y'igihe kirekire aracyakemurwa. Ntabwo ari byinshi bitewe n'amakosa y'ibiyobyabwenge, n'ubushobozi bwa virusi mutate. Byongeye kandi, benshi bamaze kwemerwa kandi ibizamini by'inkingo gusa bikoreshwa nk'intego y'iribari kimwe.
Turimo kuvuga imiterere yihariye kuri shell ya capsid ya virusi, ishinzwe kunyereza selile yanduye - kwakira indangarubuga (RBD). Utwo turere tugahora duhinduka kandi dushobora gutandukana cyane hagati yimiterere ya virusi imwe, tutavuga amoko ajyanye nayo. Kubwibyo, abashakashatsi b'Abanyamerika bibanze ku mikorere yo kurema antibodiyidi ishobora kuba itandukanye.
Abakozi nkabo bitwa Antibodiyine mugari (kugamana ubugome, Bnabs) kandi birashobora kuba ishingiro ryinkingo zose zingana zo kurengera ako kanya mumuryango wa virusi zose. Kandi mu bushakashatsi bumaze igihe, byashobokaga gukora abakandida benshi: ADG-1, ADG-2 na ADG-3. Nkibisubizo byo guhitamo, guhuza na ADG-2 byari byiza cyane.
Ubushobozi bwayo bwo gutera coronasirus bwagenzuwe kumuco wimbeba yimbeba, kandi birashimishije. ADG-2 ihuza neza ibice birenga bitatu bya cumi na bitatu bya smar-cov-2, ubu ikaba itera ubwoba ikimuntu. Abahanga mu bya siyansi bahuye n'umubiri utanga icyizere ku mibereho itandukanye, aho RBD itandukanye cyane. Igishimishije cyane, ADG-2 yerekanye ubushobozi bukabije bwo guhuza "abavandimwe" batandukanye ba COVI - 19 - SarBecovirus virusi ya virusi.
Inkomoko: Ubumenyi bwambaye ubusa