Asayansi anena za mayi waku Russia momwe kornavirus adapeza masinthidwe atsopano

Asayansi anena za mayi waku Russia momwe kornavirus adapeza masinthidwe atsopano

Asayansi ochokera ku Spolkovsk Ins of Science ndi ukadaulo, Institute of the Stockich chidziwitso cha sayansi ya Run , momwe adauza wodwala wazaka 47 wokhala ndi Covid Nine. Chowonadi ndi chakuti, Aronavirus adapeza ma 4 masinthidwe a 18, ndipo amadwala kwa miyezi yopitilira anayi.

Kumapeto kwa Marichi chaka chatha, mkazi yemwe ali ndi B-cell nehdgkinsky nehodgkinsky strade castern adagonekedwa m'chipatala cha Chemotherapy Ritotepy (antitumor ochokera ku mantibodies). Anagona m'chipinda chimodzi ndi wodwala wokalamba, yemwe posakhalitsa adawululira Covid-19.

Pa Epulo 17, mayi wazaka 47 adachotsedwa kuchipatala, koma osakwana milungu iwiri adapezekanso matenda a Coronzavirus. "Pofika nthawi imeneyo, zimawoneka ngati zizindikiro za Covid-19 (kutentha kwa thupi). Chitsanzo ichi chidatayidwa atayesedwa ndipo sichinapezeke. Kubwereza Strokong Strokos May 14, Meyi 19, June 9 ndi Julayi 14, adapereka zotsatira zoyipa pa SARS-Cov-2. Komabe, wodwala wazaka 25 mpaka pa Ogasiti 21, zizindikiro za Coviid kwambiri-19 zidawonedwa. Zotsatira zake zinali zabwino 3, 5, 8, 13, 13, 20, 20, 21, a August 27, komanso pa Seputembara 3 ndi 9. Pomaliza, zotsatirapo zake zinali zovuta pa Seputembara 12, kenako nkukonzanso zaka 10 ndi Disembala 16, "olemba phunziroli alemba.

Udindo wa zitsanzo za wodwala wazaka 47 mu mzere B.1.1. Mtengo wa phylogenetic B.1.1, yokonzedwa ndi mahekitala 49,083, adadulidwa kuti akhale ndi 1% ya zitsanzo zosasinthika, kuphatikizapo zitsanzo kuchokera kwa wodwala s (red dot). Wodwala ndi maziko akuda. Mzere wa wodwalayo ali ndi masinthidwe 18, kuphatikiza Δ69-70hv ndi Y. Line B.1.1.7 ndi tsango 5 shadd / © Basykin g.a. ena

Asayansi adatsatira chiwembu cha makampani omwe adalandira pa Ogasiti 20 kuchokera ku Nasopharynx. Poyerekeza, nawonso anatsatiranso zitsanzo za mkazi (wodwala a), omwe wodwala wazaka 47 ali mwina ndi kachilomboka. Zotsatira zake, zidapezeka kuti kuchokera ku zomwe zatchulidwazi, ohan shain SARS-COV-2, chitsanzo cha Russia kusiyanitsa zosintha 25. "Mwa awa, mitundu isanu ndi iwiri ya polymorisms osakwatiwa, kuphatikiza atatu mwa maudindo oyandikana 21881-21883, amaikidwa muyezo wa wodwala mu mzere B.1.1. Gennome imanyamula zosintha zotsalira 18. Chitsanzo cha wodwala woyamba ndipo adayikidwa m'munda wa B.1.1, ndikutsimikizira kuti masinthidwe 18 amafotokoza za wodwala, "akatswiri amafotokoza za wodwala."

Chifukwa chake, omwe adalipo lipotilo, kotsatiridwa ndi coronavirus genome kuchokera kwa wodwalayo ndi mawu odziyimira pa intaneti oyambira kuyambira pa Epulo 10: Izi zikufanana ndi liwiro la 1.67e-3 Nyuzo za Nucleotide pachaka, zomwe zimaposa zosintha zapamwamba kwambiri za eloir-cov-2. Kuphatikiza masinthidwe a S-Protein Y453f ndi Δ69-70hv ("kuphatikiza Δf"), omwe adawululidwa mu Mincanavirus yoyipitsidwa.

"Masinthidwe onse awiri amapezeka mwa wodwala kwambiri wokhala ndi intaneti yapakati: izi ndi vuto la polymorphism mkati mwa alendowo. Popeza kuwunika phylogenetic kwawonetsa kuti wogogoda wa wodwalayo sakugwirizana ndi tsango la mink, masinthidwe adapangidwanso. Kupeza pawokha kwa zosintha zofanana ndi zosintha mu mink ndi wodwala matenda a lymphoma, komanso pakati pa odwala angapo omwe ali ndi chitetezo chovuta, chimaphatikizapo kusintha kogwirizana pakusankha. Wodwalayo amaperekanso zitsanzo zokhazokha lero ndi zosintha za Y453F ndi SORS: Δ69-70hv kunja kwa tsango 5, ndiye kuti, amapezeka molunjika payekha,

Spikelsts in coronaviikhwents variants ndi mitundu yolembetsa yomwe imadziwika kuti yotchedwa kovidid-19. Kuwonetsa masinthidwe a amino acid mndandanda wa Spike Gene. Mizere kuchokera pamwamba mpaka pansi: 50y: VORARARD V2; Ver-202012/01 (Britanda); Njira ya tsambali 5; Wodwala wokhala ndi vuto lofooka, kulandira plasma kutulutsidwa; Wodwala ndi chitetezo chofowoka, kulandira osakaniza a ma antibododies Regenern; Wodwala ndi chitetezo chofooka, kulandira ma plsma kuti achira; Wodwala wokhala ndi chitetezo chofooketsa omwe sanalandire chithandizo ndi ma prosma kapena ma antibodies obwezeretsa. Mitundu yowala yowoneka bwino yokhazikika mu maphunziro awiri / © Basykin g.a. ena

Kuphatikiza apo, wodwalayo adawululiranso masinthidwe awiri, omwe m'mbuyomu adapezanso odwala ena-19 okhala ndi chitetezo chofooka, kuphatikiza n501y. Kusintha kumeneku kulipo mu zovuta zomwe zimatchedwa Britain ku Coronavirus ndi mtundu waku South Africa.

"Popeza masinthidwe onsewa amagulidwa ndi zokambirana (ndizofanana ndi genotype. - Apple. Ed. Ed.) Chifukwa chake, zimathandizira kuti odwala akhale osakanizidwa, koma amasiyana Kuchokera pamenepo mwa anthu. Komabe, zosankha zodziwika mwa odwala omwe ali ndi chitetezo chofookeza (ndi mink) amatha kufalikira kwa chiwerengero chofala, "olemba maphunziro omwe adakambirana.

Mutu wa gulu la sayansi basykin, pulofesa wa Slolkovsky Institute of Science ndi ukadaulo, zomwe zatchulidwa mu ndemanga za Media, monga zafotokozedwera - osakwatiwa - osakwatiwa. "Kwa mkhalidwe wa miliri wamba, sizimayimira kufunika kofunikira kwambiri. Tikukhulupirira kuti kachilomboka, komwe kunachokera mthupi la wodwala uyu, sanapite kulikonse. M'malo mwake, awa ndi kuyesa kumvetsetsa momwe kachilomboka ukulowera komanso kusankha kwachilengedwe kukuchitika, "adapindika.

Source: Sayansi yamanyazi