Chokhacho chachikulu kwambiri chochokera ku squid chingathandize poti matenda a ubongo

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Chokhacho chachikulu kwambiri chochokera ku squid chingathandize poti matenda a ubongo 4868_1
Chokhacho chachikulu kwambiri chochokera ku squid chingathandize poti matenda a ubongo

Ntchitoyi idathandizidwa ndi zopereka za pulogalamu ya Purezidenti ya maziko a ku Russia (RNF) ndikusindikizidwa mu magazini ya sayansi ya sayansi. Kuvulala kwa kutentha ndi ubongo kumawonedwa ngati koopsa kwambiri, chifukwa zimatha kuwongolera mawonekedwe a kuzindikira, zakuthupi komanso zamaganizidwe. Nthawi zambiri kuvulala koteroko kumachitika ndi kuthamanga kapena kuchepa, kukakamiza, kuvulala kopusa kapena kuwonongeka kolowera.

Nthawi yomweyo, 80-90 peresenti ya milandu imagwera kuvulala kopepuka ndipo amatsagana ndi neuropetion yayitali (kutupa mu ubongo), komwe kungakhale kofooka kwa wodwalayo. Zikatero, kusowa kwa chithandizo cha nthawi yake kumatha kuyambitsa matenda ovuta - kufa kwa ma neuron, kuwonongeka kwa ndende, mutu wokhazikika, minofu yosiyanasiyana, ndi zina zopweteka.

Mwa kuyankha kotupa ndi kuvulala kwamkati, ma microgelia ndi odalirika. Ili ndi gulu la maselo omwe amamwa (phagocytic) achilendo komanso maselo omwe akumwalira. Pambuyo povulala ikapezeka, chitetezo chamthupitichi chimayambitsidwa, chomwe chimafunikira mkati mwabwinobwino. Microglia imayambitsa njira yobwezeretsanso zowonongeka - kuyeretsa kuchokera ku zotupa ndi kutulutsa ma cytokines otupa omwe amagwira ntchito yoteteza nthawi yayitali.

Komabe, m'malo ovuta, chitetezo cha mthupi chimachulukitsa njira chifukwa cha kutupa kwambiri. Pankhani imeneyi, ndikofunikira kukulitsa mankhwala omwe amatha kuphatikizidwanso komanso kusintha zomwe zimachitika maselo otupa.

Ofufuzawo ochokera ku National Sayansi Yachilengedwe Yotchulidwa pambuyo pa A. V. Zhurminsky kutali kwambiri ndi makonda a sayansi Mmodzi mwazinthu zoterezi ndi sunnamide - ichi ndi chinthu chofanana ndi chofanana ndi ma neurotransmitter (zinthu zomwe zimapangitsa kuti nsomba ya electrochemical imafalikira pakati pa maselo amitsempha).

Zimayambitsa ma cell atsopano amitsempha ndi ma synupses, komanso kufalikira (ma neuron neuron (neurons ma neurons akupanga njira zina kuchokera kuma cell ena mu unyolo). Kuti mupeze chinthu, kukhazikika kwa mafuta am'madzi a acid ochokera ku chiwindi wa squid asitikali adagwiritsidwa ntchito. Pambuyo pake, docoscenthexaenic acid adapangidwa kuchokera kwa omwe asankhidwa, omwe amaphatikizidwa mu cell nembanemba za minofu yamanjenje. Acid ino yakhala maziko a mankhwalawa.

Asayansi adafufuzidwa, monga kugwiritsa ntchito mankhwalawa, maluso a makoswe a makoswe ndi kuvulala kwaubongo kumasintha. Pachifukwa ichi, masana, adavalidwa ndi nyama masiku asanu ndi awiri atavulala kwambiri muubongo. Kafukufuku wapitawo wasonyeza kuti kuvulala kumawonjezera kuchuluka kwa nkhawa m'makoswe, chifukwa chake, ofufuzawo adasintha, komanso kuyesedwa kwakanthawi komanso kwakanthawi. Poyamba, makoswe adakhazikitsidwa kukhala labyrinth-wowoneka bwino - zida zapadera ndi madipatimenti awiri otseguka komanso awiri otsekeka.

Chokhacho chachikulu kwambiri chochokera ku squid chingathandize poti matenda a ubongo 4868_2
Squid ndi Silphamid Molekyu / © Igor Manzhulo / Nncmb

Ndi kuchuluka kwa nthawi yomwe imagwiritsidwa ntchito pamasamba otseguka, asayansi adatsimikiza kuchuluka kwa nkhawa: Thele bata kwambiri komanso nthawi yochulukirapo sizibisike mu "manja", zimachepetsa nkhawa. Pambuyo pake, makoswe adayikidwa mu chipangizocho chogawidwa m'malo amdima komanso opepuka. Makoswe atadutsa chitseko chomwe chidalowa m'chipinda chamdima, adakhudzidwa ndi zotulutsa zamagetsi zamagetsi. Kuwona machitidwe a nyama, ofufuzawo adayang'anira ngati makoswe awo akukumbukira, omwe adalandira kupsinjika kowawa.

"Simitum imathandizira kukumbukira kwa nthawi yayitali ndikuchepetsa nkhawa. Imaletsanso ntchito ya microglia Pro-yotupa ma cell a ma cytokines - izi zidawonetsa kuyesa kwathu kwa ma contokines - izi zidawonetsa kuyesa kwathu kwa ma contokines - izi zidawonetsa kuyesa kwathu kwa ma clowec - izi zidawonetsa kuyesa kwathu kwazomwe timapanga kuzindikira kofanana ndi ubongo.

Idor Manurolo, anatiteteza bwanji. Mwa sayansi yazomera, manejar a polojekiti a Ranf Perg, wogwira ntchito Sukulu ya labotale ya labotale ya pharman a Sukulu ya Russian Academs ya sayansi.

Source: Sayansi yamanyazi

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