Acetate - ethanol metabolite, wanda Aldh2 enzeme ya samar. Yana hulɗa tare da mai da-amine mai-amine (Gamar) - Ganyen birki na tsarin juyayi na tsakiya. Shi ne ke da alhakin yadda ya buge shi. Misali, mutanen da suka birgewa daga giya ana lura da rashi Aldh1. Don haka ba za su iya samun sauri haifar da matsala ba.
Tun da farko an yi imani da cewa ethanol metabolism faruwa ne a hanta, kuma akwai riga an lalata samfuran su. Duk da haka, wani rukuni na Amurka neurobololist masana masana ilimin Amurka daga Cibiyoyin Aljannar Alasa na Kasa sun gano cewa hadawan abu da iskarwarmu na iya faruwa a cikin kwakwalwa. Ya juya, an bayyana shi a cikin kwanakin chebellum kuma yana haifar da asarar daidaituwa. Cikakkun bayanai na bude an buga su a cikin Jaridar Yanayi na Nasara.
Masana kimiyya sun bincika furcin Mrna Aldh2 a bangarori daban-daban na kwakwalwar kwaritawa da bangon kwakwalwar kwakwalwar mutum uku. Ya juya cewa an bayyana sunan a cikin cheebellum, kuma mafi karancin a cikin ɓawon burodi na farko.
Hakanan, kungiyar gudanar da gwaji ne akan mice. A saboda wannan, masana kimiya sun kawo rodents, a cikinsu da kwakwalwa ba enz2 enz2 ba. Sa'an nan kuma su da dabbobin talakawa aka ba su karamin adadin ethanol (gram daya a kowace kilogram na nauyi). Yayin bincike, ya juya cewa barasa ta motsa bayyanar acetate a cikin cerebell. Koyaya, mice da aka samo ya zama mafi tsayayya ga tasirin barasa, tunda enzyme kusan bai juya giya cikin matsala ba, wanda aka tara a cikin kwakwalwa. A cikin rodents ba tare da Astrocytic Aldh2 ba, akwai ƙananan matakin caca a cikin kwakwalwa bayan amfani da barasa. Saboda haka mafi kyawun daidaituwa.
A cikin mice tare da karancin enzyme a hanta, irin wannan dogaro an lura. Wannan ya ba wa marubutan binciken don ɗauka cewa tushen Acetate a cikin cerebellum - barasa, kuma ba alkarya. Amma har yanzu dole ya tabbatar.
A ƙarshe, masana kimiyya sun ƙare ga kammalawa cewa AlDh2 enzeme, wanda ke cikin hanta da kwakwalwa, yana shafar jiki ta hanyoyi daban-daban. Sun yi niyyar ci gaba da binciken wannan enzyme a cikin mutane. Hakanan, masana da ake kira Aldh2 muhimmiyar manufa don lura da jarabar giya da cututtukan neurological.
Source: Kimiyya mara kyau